Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS.
Identifieur interne : 005231 ( Main/Exploration ); précédent : 005230; suivant : 005232Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS.
Auteurs : Alexander Bukreyev [États-Unis] ; Elaine W. Lamirande ; Ursula J. Buchholz ; Leatrice N. Vogel ; William R. Elkins ; Marisa St Claire ; Brian R. Murphy ; Kanta Subbarao ; Peter L. CollinsSource :
- Lancet (London, England) [ 1474-547X ] ; 2004.
Descripteurs français
- KwdFr :
- ADN recombiné, Administration par voie nasale, Animaux, Anticorps antiviraux (sang), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (immunologie), Glycoprotéines membranaires (métabolisme), Immunité muqueuse, Irrigation thérapeutique, Muqueuse nasale (virologie), Muqueuse respiratoire (immunologie), Protéines de l'enveloppe virale (immunologie), Protéines de l'enveloppe virale (métabolisme), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Trachée, Vaccination, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Vaccins atténués, Vaccins contre les virus para-influenza, Virus du SRAS (immunologie), Virus du SRAS (isolement et purification), Virus du SRAS (métabolisme), Virus parainfluenza bovin de type 3 (immunologie), Virus parainfluenza bovin de type 3 (isolement et purification), Virus parainfluenza bovin de type 3 (métabolisme).
- MESH :
- administration et posologie : Vaccins antiviraux.
- immunologie : Glycoprotéines membranaires, Muqueuse respiratoire, Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virus du SRAS, Virus parainfluenza bovin de type 3.
- isolement et purification : Virus du SRAS, Virus parainfluenza bovin de type 3.
- métabolisme : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus du SRAS, Virus parainfluenza bovin de type 3.
- sang : Anticorps antiviraux.
- virologie : Muqueuse nasale.
- ADN recombiné, Administration par voie nasale, Animaux, Glycoprotéine de spicule des coronavirus, Immunité muqueuse, Irrigation thérapeutique, Syndrome respiratoire aigu sévère, Trachée, Vaccination, Vaccins atténués, Vaccins contre les virus para-influenza.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Antibodies, Viral (blood), Chlorocebus aethiops, DNA, Recombinant, Immunity, Mucosal, Membrane Glycoproteins (immunology), Membrane Glycoproteins (metabolism), Nasal Mucosa (virology), Parainfluenza Vaccines, Parainfluenza Virus 3, Bovine (immunology), Parainfluenza Virus 3, Bovine (isolation & purification), Parainfluenza Virus 3, Bovine (metabolism), Respiratory Mucosa (immunology), SARS Virus (immunology), SARS Virus (isolation & purification), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Spike Glycoprotein, Coronavirus, Therapeutic Irrigation, Trachea, Vaccination, Vaccines, Attenuated, Viral Envelope Proteins (immunology), Viral Envelope Proteins (metabolism), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Viral Vaccines.
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Membrane Glycoproteins, Viral Envelope Proteins, Viral Vaccines.
- chemical , metabolism : Membrane Glycoproteins, Viral Envelope Proteins.
- immunology : Parainfluenza Virus 3, Bovine, Respiratory Mucosa, SARS Virus, Severe Acute Respiratory Syndrome.
- isolation & purification : Parainfluenza Virus 3, Bovine, SARS Virus.
- metabolism : Parainfluenza Virus 3, Bovine, SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Nasal Mucosa.
- Administration, Intranasal, Animals, Chlorocebus aethiops, DNA, Recombinant, Immunity, Mucosal, Parainfluenza Vaccines, Spike Glycoprotein, Coronavirus, Therapeutic Irrigation, Trachea, Vaccination, Vaccines, Attenuated.
Abstract
The outbreak of severe acute respiratory syndrome (SARS) in 2002 was caused by a previously unknown coronavirus-SARS coronavirus (SARS-CoV). We have developed an experimental SARS vaccine for direct immunisation of the respiratory tract, the major site of SARS- coronavirus transmission and disease.
DOI: 10.1016/S0140-6736(04)16501-X
PubMed: 15220033
Affiliations:
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qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Muqueuse respiratoire</term><term>Protéines de l'enveloppe virale</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term><term>Virus parainfluenza bovin de type 3</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Parainfluenza Virus 3, Bovine</term><term>Respiratory 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antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Muqueuse nasale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nasal Mucosa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Chlorocebus aethiops</term><term>DNA, Recombinant</term><term>Immunity, Mucosal</term><term>Parainfluenza Vaccines</term><term>Spike Glycoprotein, Coronavirus</term><term>Therapeutic Irrigation</term><term>Trachea</term><term>Vaccination</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN recombiné</term><term>Administration par voie nasale</term><term>Animaux</term><term>Glycoprotéine de spicule des coronavirus</term><term>Immunité muqueuse</term><term>Irrigation thérapeutique</term><term>Syndrome respiratoire aigu sévère</term><term>Trachée</term><term>Vaccination</term><term>Vaccins atténués</term><term>Vaccins contre les virus para-influenza</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The outbreak of severe acute respiratory syndrome (SARS) in 2002 was caused by a previously unknown coronavirus-SARS coronavirus (SARS-CoV). We have developed an experimental SARS vaccine for direct immunisation of the respiratory tract, the major site of SARS- coronavirus transmission and disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Buchholz, Ursula J" sort="Buchholz, Ursula J" uniqKey="Buchholz U" first="Ursula J" last="Buchholz">Ursula J. Buchholz</name><name sortKey="Collins, Peter L" sort="Collins, Peter L" uniqKey="Collins P" first="Peter L" last="Collins">Peter L. Collins</name><name sortKey="Elkins, William R" sort="Elkins, William R" uniqKey="Elkins W" first="William R" last="Elkins">William R. Elkins</name><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R" last="Murphy">Brian R. Murphy</name><name sortKey="St Claire, Marisa" sort="St Claire, Marisa" uniqKey="St Claire M" first="Marisa" last="St Claire">Marisa St Claire</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Vogel, Leatrice N" sort="Vogel, Leatrice N" uniqKey="Vogel L" first="Leatrice N" last="Vogel">Leatrice N. Vogel</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Bukreyev, Alexander" sort="Bukreyev, Alexander" uniqKey="Bukreyev A" first="Alexander" last="Bukreyev">Alexander Bukreyev</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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